发明名称 |
ASSAY FOR LOW MOLECULAR WEIGHT HEPARIN |
摘要 |
A prothrombin time reagent for determination of low molecular weight heparin in fresh whole blood and in anti-coagulant treated blood is provided. The reagent is composed of recombinant animal tissue factor, and a mixture of synthetic phospholipids, which mixture includes a phosphatidylalcohol. A formulation buffer which includes a sensitivity adjuster is used in formulating the reagent. The recombinant animal tissue factor includes rabbit brain. The synthetic phospholipids of the mixture include palmitoyloleoylphosphatidylcholine (POPC), palmitoyloleoyl-phosphatidylserine (POPS), and a phosphatidylalcohol. The phosphatidyl alcohol includes dioleoylphosphatidylethanol, dioleoylphosphatidylmethanol, dioleoylphosphatidylpropanol, dioleoylphosphatidylbutanol, and dioleoylphosphatidylinositol. The sensitivity adjuster included in the formulation buffer is gamma-Cyclodextrin. The formulated reagent is air-dried and remains stable for at least 3 weeks at 37°C. |
申请公布号 |
WO2004016800(A3) |
申请公布日期 |
2004.04.29 |
申请号 |
WO2003US21919 |
申请日期 |
2003.07.15 |
申请人 |
INTERNATIONAL TECHNIDYNE CORPORATION |
发明人 |
LEE, TED, C.K.;MCBRIDE, AMANDA, B.;LADUCA, FRANK, M. |
分类号 |
C12Q1/56;G01N33/86 |
主分类号 |
C12Q1/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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