| 摘要 |
Disclosed is a method of screening binding molecules, including Monoclonal Antibodies, using an optical fiber array device. Target cells are coated onto a population of microbeads, wherein each microbead is coated with several cells of the same cellular type and has an assay and an assay reporter associated with it. Each of the cell-coated microbeads is positioned in a particular well formed in one end of a particular fiber in an array of optical fibers. The microbeads are contacted with binding molecules, and the results of an assay associated with a microbead are reported to the distal end of the array of fibers. |
