MODULATION OF TGFBETA-LIKE SIGNALLING PATHWAYS

摘要

The present invention relates to the a new family of polypeptides which are extra-cellular modulators of members of the Transforming Growth Factor ß (TGFß) superfamily, including TGFßs and BMPs, and are involved in embryogenesis and the pathogenesis of human disorders mediated by TGFß superfamily signalling. These modulators are termed Tsukushi (TSK) polypeptides. Agents and methods for modulating (TGFß)-like molecule signalling pathways using TSK polypeptides are provided.