| 发明名称 |
PROTEIN MODIFICATION |
| 摘要 |
The present invention relates to a method for changing the half-life of a glycosylated compound by the modification of its O-linked carbohydrates. Thi s modification is preferably carried out enzymatically and aimed at extending the half-life of the com~pound. Both in vivo and in vitro modification protocols may be used.
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| 申请公布号 |
CA2502539(A1) |
申请公布日期 |
2004.04.29 |
| 申请号 |
CA20032502539 |
申请日期 |
2003.10.17 |
| 申请人 |
PHARMING INTELLECTUAL PROPERTY B.V. |
发明人 |
PIEPER, FRANK;MANNESSE, MAURICE;VAN BERKEL, PATRICK |
| 分类号 |
A61K38/17;A61K38/55;C07K14/81;C12N9/10;C12P19/00;C12P19/44;C12P21/00;C12P21/02;(IPC1-7):C12P21/00 |
主分类号 |
A61K38/17 |
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