发明名称 |
Group B Streptococcal phage lysin |
摘要 |
The present disclosure relates to the identification phage lysin from group B streptococci (GBS). The nucleic acid sequence and amino acid sequence of the GBS phage lysin is disclosed. The GBS phage lysin is a bifunctional protein comprising a glucosidase and an endopeptidease activity. The endopeptidase present in the GBS phage lysis has a substrate specificity that has not been previously reported. The bifunctional GBS phage lysin is effective against groups A, B, C, E and G streptococci. Also described are methods of using the GBS phage lysin for the prevention and treatment of bacterial infections.
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申请公布号 |
US2004081646(A1) |
申请公布日期 |
2004.04.29 |
申请号 |
US20030650559 |
申请日期 |
2003.08.28 |
申请人 |
ENGLER JEFFREY A.;SCHWEBKE JANE R.;BAKER JOHN R.;PRITCHARD DAVID G. |
发明人 |
ENGLER JEFFREY A.;SCHWEBKE JANE R.;BAKER JOHN R.;PRITCHARD DAVID G. |
分类号 |
A61K38/00;A61K39/00;C07H21/04;C12N9/50;C12P21/04;(IPC1-7):A61K38/48;C12N9/48 |
主分类号 |
A61K38/00 |
代理机构 |
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