KRISTALLINES (-)-3R,4R-TRANS-7-METHOXY-2,2-DIMETHYL-3-PHENYL-4[4-(2-PYRROLIDIN-1-YL)ETHOXY] PHENYL-CHROMAN-WASSERSTOFFUMARATE

摘要

The present invention provides novel crystalline (-)-3R,4R-trans-7-methoxy-2,2-dimethyl-3-phenyl-4-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}chromane, hydrogen fumarate useful for reducing or preventing bone loss as well as pharmaceutical compositions containing the same. A process for preparing (-)-3R,4R-trans-7-methoxy-2,2-dimethyl-3-phenyl-4-{4-[2-(pyrrolindin-1-yl)ethoxy]phenyl}chromane, hydrogen fumarate is described.