发明名称 |
PRE-ORGANIZED TRICYCLIC INTEGRASE INHIBITOR COMPOUNDS |
摘要 |
Tricyclic compounds according to the structure below, protected intermediate s thereof, and methods for inhibition of HIV-integrase are disclosed. Formula (I). Al and A2 are moieties forming a five, six, or seven membered ring. L i s a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl. Q is N, +NR, or CR4. The ary l carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.
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申请公布号 |
CA2501881(A1) |
申请公布日期 |
2004.04.29 |
申请号 |
CA20032501881 |
申请日期 |
2003.10.16 |
申请人 |
GILEAD SCIENCES, INC. |
发明人 |
CHEN, JAMES M.;CHEN, XIAOWU;FARDIS, MARIA;JIN, HAOLUN;SCHACHERER, LAURA N.;KIM, CHOUNG U. |
分类号 |
C07D207/40;C07D207/404;C07D471/00;C07D471/04;C07D487/04;(IPC1-7):C07D471/04;C07D498/20 |
主分类号 |
C07D207/40 |
代理机构 |
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