发明名称 |
Modulation of hedgehog-mediated signaling pathway |
摘要 |
The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
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申请公布号 |
US2004082036(A1) |
申请公布日期 |
2004.04.29 |
申请号 |
US20030677982 |
申请日期 |
2003.10.01 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE;BAYLOR COLLEGE OF MEDICINE |
发明人 |
BEACHY PHILIP A.;TSAI MING-JER;TSAI SOPHIA;KRISHNAN VENKATESH;CHEN CHIEN-HUAN |
分类号 |
C07K14/435;C07K14/46;C07K14/47;G01N33/573;G01N33/68;(IPC1-7):A61K38/46;C07H21/04;C07K14/705 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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