PH-SENSITIVE POLYMERIC CONJUGATES OF AN ANTHRACYCLINE DRUG

摘要

Conjugates consisting of a polymeric carrier constituted by 30 to 3,000 monomer units linked to form a polymeric chain, composed of a) 60 to 99 % of N-(2-hydroxypropyl)methacrylamide units, b) 1 to 25% of units of methacryloylated hydrazones of alpha -amino acids, epsilon -amino acids, aromatic amino acids or oligopeptides terminated with a molecule of an anthracycline cancerostatic, c) 0.5 to 15 % of units of methacryloylated alpha -amino acids, epsilon -amino acids, aromatic amino acids or oligopeptides or their sodium salts.