RETINOID INDUCIBLE PROTEINS OF VASCULAR SMOOTH MUSCLE CELLS AND USES THEREOF

摘要

The present invention relates to an isolated retinoid inducible serine carboxypeptidase proteins or polypeptides, and the nucleic acid molecules encoding such a protein or polypeptide. Nucleic acid constructs, expression systems and host cells containing those nucleic acid molecules, and antibodies raised against the proteins or polypeptides are also disclosed. The present invention also relates to methods for detecting a vascular disease or disorder, inhibiting smooth muscle cell growth, treating vascular hyperplasia, and inhibiting the activity of extracellular regulated kinase. The present invention also relates to a transgenic non-human animal lacking a gene encoding a retinoid inducible protein or polypeptide.