ASPARAGINYL HYDROXYLASES AND MODULATORS THEREOF

摘要

A method of identifying, screening, characterising or designing a chemical entity, which mimics or binds to FIH, is described. The method comprises comparing a structural model of FIH with a structural model for said chemica l entity, wherein said structural model of FIH is derived from structural factors or structural coordinates determined by subjecting to X-ray diffraction measurements a crystal comprising FIH. Such chemical entities ma y be used in the treatment of a condition associated with increased or decreas ed HIF levels or activity.