发明名称 |
STABILIZED EXENDIN-4 COMPOUNDS |
摘要 |
The present invention disclosed compositions comprising a stabilized Exendin -4 (1-39) and related compounds. The invention describes stabilized Exendin-4 agonists that include at least one modified amino acid residue particularly at positions Gln 13, Met14, Trp25, or Asn28 of the Exendin-4 (1-39) molecule. Disclosed are preferred modifications of deaminated, hydrolyzed, oxidized, o r isomerized reaction products of the specified amino acid residues corresponding to the same positions in the Exendin-4 molecule. The invention also relates to methods of making and using the stabilized Exendin compounds , such as for the treatment of diabetes.
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申请公布号 |
CA2500295(A1) |
申请公布日期 |
2004.04.29 |
申请号 |
CA20032500295 |
申请日期 |
2003.10.02 |
申请人 |
ZEALAND PHARMA A/S |
发明人 |
KNUDSEN, CARSTEN BOYE;JEPSEN, TRINE;KNOTT, DAVID;EBBEHOJ, KIRSTEN;LARSEN, BJARNE DUE |
分类号 |
A61K38/22;C07K14/575;(IPC1-7):C07K14/575;A61P3/10;C07K1/107 |
主分类号 |
A61K38/22 |
代理机构 |
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地址 |
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