发明名称 |
PHOSPHITYLATION PROCESS |
摘要 |
<p>A process for the phosphitylation of an alcohol or thiol with a phosphitylation agent in the presence of an activator is provided. The activator has the formula (1): wherein p is 0 or an integer from 1 to 4 and R for each occurrence is a substituent. Preferably X<7> is O and p is 0. The activator is commonly employed as a salt complex with an organic base. Preferred alcohols or thiols include nucleosides and oligonucleotides. The process is particularly suited for the synthesis of phosphoramidites.</p> |
申请公布号 |
WO2004035599(A1) |
申请公布日期 |
2004.04.29 |
申请号 |
WO2003GB04312 |
申请日期 |
2003.10.08 |
申请人 |
AVECIA BIOTECHNOLOGY INC.;AVECIA LIMITED;SINHA, NANDA, DULAL |
发明人 |
SINHA, NANDA, DULAL |
分类号 |
C07F9/24;C07H19/06;C07H19/16;(IPC1-7):C07H19/06 |
主分类号 |
C07F9/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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