发明名称 |
PROCESS FOR THE PREPARATION OF (S,S)-CIS-2-BENZHYDRYL-3-BENZYLAMINOQUINUCLIDINE |
摘要 |
A process for preparing (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine. Th e process includes the steps of contacting a compound containing a mixture of R- and S-isomers and having Formula (I), with an effective amount of a chiral organic acid in the presence of an organic solvent and an effective amount o f an organic carboxylic acid for converting the R-isomer into an acid salt of the S isomer, wherein the organic solvent is capable of solubilizing the compound containing the mixture of R- and S-isomers, while precipitating the acid salt and the organic carboxylic acid is different from the chiral organ ic acid; neutralizing the acid salt with a base to provide an S-isomer of a chiral ketone of Formula (II), and reacting the chiral ketone with an organi c amine in the presence of a Lewis acid to provide the corresponding imine and reducing the imine.
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申请公布号 |
CA2500635(A1) |
申请公布日期 |
2004.04.29 |
申请号 |
CA20032500635 |
申请日期 |
2003.10.10 |
申请人 |
PFIZER PRODUCTS INC.;DSM PHARMACEUTICALS, INC. |
发明人 |
NUGENT, THOMAS C.;SEEMAYER, ROBERT |
分类号 |
C07D453/02;(IPC1-7):C07D453/02 |
主分类号 |
C07D453/02 |
代理机构 |
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地址 |
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