| 摘要 |
A process for producing a 2-oxobicyclo[3.1.0]hex-3-ene-6-carboxylic acid derivative represented by a formula: (wherein R<1 >represents a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, a C3-6 cycloalkyl C1-6 alkyl group, a C1-6 alkyl group substituted with a substituted or unsubstituted phenyl group, a C1-6 alkoxy C1-6 alkyl group, a C1-6 hydroxyalkyl group, a C1-6 alkylthio C1-6 alkyl group, a C1-6 mercaptoalkyl group, or a substituted or unsubstituted phenyl group) characterized by reacting a 4-hydroxy-2-oxobicyclo[3.1.0]hexane-6-carboxylic acid derivative represented by a formula: (wherein R<1 >has the same meaning as described above, and R<2 >represents a hydrogen atom or a protective group of a hydroxyl group) in the presence of an acid or a base. A process for producing the compounds which are useful for efficient syntheses of 2-amino-3-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acids is provided.
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