Inflammatory inhibition factor fwa116

摘要

The present invention relates to a polypeptide of the inflammatory inhibition factor Fwa116 and the polynucleotides encoding thereof. The present invention also relates to the method of producing polypeptide Fwa116 by recombinant technology and the antibody against it and an antagonist. The present invention also discloses pharmaceutical compositions containing the polypeptide Fwa116 and the use of the polypeptide in treating cardiovascular inflammatory arterosclerosis such as cerebral apoplexy, coronary heart disease, angina pectoris, myocardial infarction and controlling tumors. The present invention also provides the diagnosing and measuring method by detecting the mutation of nucleic acid sequence encoding Fwa116 or the content of the polypeptide Fwa116 and changes in levels of the auto-antibody of the gene product of Fwa116. The present inflammatory inhibition factor is human-derived.