| 发明名称 |
Benzodiazepine derivatives as app modulators |
| 摘要 |
A novel class of 1,4- and 1,5-benzodiazepines of formula (I) is disclosed. The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence find use in the treatment or prevention of conditions associated with the deposition of beta-amyloid, such as Alzheimer's disease.
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| 申请公布号 |
US2004082572(A1) |
申请公布日期 |
2004.04.29 |
| 申请号 |
US20020296428 |
申请日期 |
2002.11.22 |
| 申请人 |
PINEIRO JOSE LUIS CASTRO;CHURCHER IAN;GUIBLIN ALEXANDER RICHARD;HARRISON TIMOTHY;KERRARD SONIA;MADIN ANDREW;NADIN ALAN JOHN;OWENS ANDREW PATE;SPAREY TIMOTHY JASON;TEALL MARTIN RICHARD;WILLIAMS SUSANNAH |
发明人 |
PINEIRO JOSE LUIS CASTRO;CHURCHER IAN;GUIBLIN ALEXANDER RICHARD;HARRISON TIMOTHY;KERRARD SONIA;MADIN ANDREW;NADIN ALAN JOHN;OWENS ANDREW PATE;SPAREY TIMOTHY JASON;TEALL MARTIN RICHARD;WILLIAMS SUSANNAH |
| 分类号 |
A61K31/55;A61K31/5513;A61K31/5517;A61P25/28;C07D243/14;C07D243/22;C07D243/24;C07D401/04;C07D401/12;C07D403/04;C07D403/12;C07D405/04;C07D405/14;C07D409/04;C07D409/12;C07D409/14;C07D413/04;C07D417/06;C07D417/12;C07D487/04;C07D491/10;(IPC1-7):A61K31/551 |
主分类号 |
A61K31/55 |
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