发明名称 |
COMPACTION PROCESS FOR MANUFACTURE OF SODIUM PHENYTOIN DOSAGE FORM |
摘要 |
A process for the roller compaction and manufacture of a pharmaceutical formulation comprises the steps of adding sodium phenytoin to a vessel of a blender and adding at least one excipient to the vessel. The mixture is blended and transferred to a roller compactor, where pressure is applied to the blend of sodium phenytoin and excipient. Next, the resultant compaction is milled to form a granulation, which is blended a second time and is suitable for further processing into a dosage form. Preferably, the excipients include magnesium stearate, sugar, lactose monohydrate, and talc. In an alternative embodiment, talc is added immediately prior to the granulation being blended for a second time. |
申请公布号 |
HU0304078(A2) |
申请公布日期 |
2004.04.28 |
申请号 |
HU20030004078 |
申请日期 |
2002.04.25 |
申请人 |
WARNER-LAMBERT CO. LLC, MORRIS PLAINS |
发明人 |
CROTTS, GEORGE HARLAND III.;FESSEHAIE, MEBRAHTU GHEBRETENSAE;GADIRAJU, SRINIVAS RAJU;GAWEL, JOHN JOSEPH;GHEBRE-SELLASSIE, ISAAC;SHETH, ASHLESH KALYANBHAI |
分类号 |
C07D233/74;A61J3/06;A61J3/07;A61J3/10;A61K9/16;A61K9/20;A61K31/4166;A61K47/02;A61K47/10;A61K47/12;A61K47/26;A61K47/38;A61P25/08 |
主分类号 |
C07D233/74 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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