发明名称 |
Process and intermediates for making substituted aspartic acid acetals. |
摘要 |
Disclosed herein is a method for making compounds that are useful as caspase inhibitor prodrugs of formula I: wherein R<SUP>1 </SUP>is an optionally substituted group selected from an aliphatic group, aralkyl group, heterocyclylalkyl group or aryl group, and R<SUP>2 </SUP>is preferably a P<SUB>2</SUB>-P<SUB>4 </SUB>moiety of a caspase inhibitor. Key intermediates include the azidolactones III and VIII: |
申请公布号 |
ZA200206658(B) |
申请公布日期 |
2004.04.28 |
申请号 |
ZA20020006658 |
申请日期 |
2002.08.20 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
MARION W WANNAMAKER;CORNELIA FORSTER |
分类号 |
C07D307/33;C07D307/66;C07F9/655 |
主分类号 |
C07D307/33 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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