VECTOR FOR ANTI-HPV(HUMAN PAPILLOMAVIRUS) VACCINE AND TRANSFORMED MICROORGANISM THEREWITH

摘要

PURPOSE: A vector for anti-HPV(human Papillomavirus) vaccine and a transformed microorganism therewith are provided, thereby expressing capsid L1 protein of human Papillomavirus on the surface of the microorganism, so that the transformed microorganism can be useful for prevention and treatment of hPV. CONSTITUTION: A vector for anti-HPV(human Papillomavirus) vaccine contains one or two gene selected from pgsB, pgsC and pgsA encoding polygammaglutamic acid synthase complex and an antigen protein gene of human Papillomavirus, wherein the antigen protein gene is one or two surface antigen protein gene selected from HPV capsid L1 and L2 or one or two antigen protein gene selected from HPV E6 and E7. The transformed microorganism with the vector for anti-HPV(human Papillomavirus) vaccine is provided, wherein the microorganism is selected from Escherichia coli, Salmonella typhi, Salmonella typhimurium, Vibrio cholera, Mycobacterium bovis, Shigella, Bacillus, Lactobacillus, Lactococcus, Staphylococcus, Listeria monocytogenes and Streptococcus.