METHOD FOR PREPARING IMMUNOGLOBULIN FOR INTRAVENOUS ADMINISTRATION OF VIRUSES IN DOUBLE STERILIZATION WITHOUT ADDITION OF ANYONE PROTECTIVE AGENT

摘要

FIELD: biotechnology, virology. SUBSTANCE: invention relates to a method for preparing biological product. Viruses are subjected for double sterilization by method using combination of pasteurization and incubation at low pH value and without using anyone protective agent. Method provides both effective destruction of viruses and retention of completeness and native biological activity of immunoglobulin, purity and safety of product. Medicinal formulation of product is a liquid one instead lyophilized powder. Glucose in the concentration 5-10% is added to the end product to maintain the equilibrium osmotic pressure of solution and to avoid undesirable effects after administration of the preparation. Method for sterilization of viruses by two different mechanisms provides the complete sterilization of virus and IVIG can be used in clinics with the enhanced effectiveness and safety. EFFECT: improved preparing method. 2 cl, 5 tbl