Heteroaryl tropane derivatives as superior ligands for nociceptin receptor ORL-1

摘要

Novel compounds of the formulawhereinR is optionally substituted heteroaryl orR<1 >is H or C1-C6 alkyl; andR<2 >and R<3 >are -CH3, -OCH3 or halo;or a pharmaceutically acceptable salt or solvate thereof, pharmaceutical compositions therefore, and the use of said compounds in the treatment of pain, anxiety, cough, asthma, depression and alcohol abuse are disclosed.