GAMMA IRRADIATION OF SOLID NANOPARTICULATE ACTIVE AGENTS
摘要
<p>The present invention relates to methods for terminal sterilization of solid forms of nanoparticulate active agent compositions via gamma irradiation. The nanoparticulate active agent has an effective average particle size of less than about 2 microns, prior to incorporation into a solid form for sterilization. The resultant sterilized compositions exhibit excellent redispersibility, homogeneity, and uniformity. Also encompassed are compositions made via the described method and methods of treating animals and humans using such compositions.</p>
申请公布号
WO2004032980(A1)
申请公布日期
2004.04.22
申请号
WO2003US27484
申请日期
2003.09.04
申请人
ELAN PHARMA INTERNATIONAL LIMITED;LEE, ROBERT;HILBORN, MATTHEW;KLINE, LAURA;KELLER, JANINE