VASOREGULATING COMPOUNDS AND METHODS OF THEIR USE

摘要

Methods and compounds are described for regulating blood pressure in a subject. Specific embodiments are methods for reversing vasodilation of bloo d vessels, by administering to a subject a therapeutically effective amount peptide AM(11-22). The vasoconstrictor can be used for a variety of purposes , including hemostasis or the treatment of shock, for example vasodilatory sho ck syndromes such as septic shock. Other specific embodiments are methods for reversing vasoconstriction of blood vessels, by administering to a subject a therapeutically effect amount of an inhibitor of AM(11-22), sufficient to reduce hypertension in the subject. Compounds and pharmaceutical composition s are also provided, as are kits.