TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS USING PGC-1 ACTIVITY-MODULATING COMPOUNDS

摘要

The invention relates to the field of biology, genetics and medicine. More specifically, the invention relates to novel methods of treating (or managing) amyotrophic lateral sclerosis. The invention also relates to methods of identifying or screening active compounds in said pathology. The invention further relates to compounds, genes, cells, plasmids or compositions that are used to carry out the above-mentioned methods. In particular, the invention describes the role of PGC1 in said pathology and the use thereof as a therapeutic target.