发明名称 |
DIASTEREOSELECTIVE METHOD OF PREPARING OLEFINS BY MEANS OF THE HORNER-WADSWORTH-EMMONS REACTION, COMPRISING THE ADDITION OF A TRIS-(POLYOXAALKYL)-AMINE SEQUESTERING AGENT |
摘要 |
The invention relates to a diastereoselective method of preparing olefins by means of the Horner-Wadsworth-Emmons reaction consisting in reacting a phosphonate on a carbonyl derivative in the presence of a base in an appropriate solvent and at a low temperature. The invention is characterised in that it comprises the addition of a tris-(polyoxaalkyl)-amine sequestering agent in a sufficient quantity to increase the diastereoselectivity of the olefin, said agent having formula (I): N-[CHR1-CHR2-O-(CHR3-CHR4-O)n-R5]3 (I), wherein: n is an integer between 0 and 10; R1, R2, R3, R4 can be identical or different and represent a hydrogen atom or an alkyl radical having between 1 and 4 carbon atoms; and R5 represents a hydrogen atom, an alkyl radical or a cycloalkyl having up to 12 carbon atoms, a phenyl radical or a radical with formula -CmH2m-F or CmH2m+1-F, m being an integer between 1 and 12 and F being a phenyl radical. |
申请公布号 |
WO2004026806(A3) |
申请公布日期 |
2004.04.22 |
申请号 |
WO2003FR02781 |
申请日期 |
2003.09.22 |
申请人 |
RHODIA CONSUMER SPECIALTIES LIMITED;TOUCHARD, FRANCOIS;BUISINE, OLIVIER;LE GUYADER, FREDERIC;SCHLAMA, THIERRY;MANFRE, FRANCO |
发明人 |
TOUCHARD, FRANCOIS;BUISINE, OLIVIER;LE GUYADER, FREDERIC;SCHLAMA, THIERRY;MANFRE, FRANCO |
分类号 |
C07C67/343;C07D213/48;C07D333/24 |
主分类号 |
C07C67/343 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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