OPTICALLY ACTIVE (R)-HYDANTOIN DERIVATIVE

摘要

PROBLEM TO BE SOLVED: To obtain an optically active substance having features, by optically resolving the optically active substance of 5-hydroxy-1-methylhydantoin useful as a medicament. SOLUTION: (R)-(+)-5-Hydroxy-1-methylhydantoin is an optical active substance having excellent renal failure evolution inhibitory action. The (R)-(+)-5-hydroxy-1-methylhydantoin significantly inhibits increase of creatinine in the blood in case of being administered to a model animal for the renal failure, when compared with an S-isomer which is an enantiomer thereof. Therefore, the substance has the excellent renal failure evolution inhibitory action to improve a creatinine clearance, and is highly available as a medicine for the renal failure of high activity. COPYRIGHT: (C)2004,JPO