发明名称 |
PEPTIDES MODULATING CASPASE ACTIVATION |
摘要 |
<p>The present invention provides structures of small molecules capable of modulating apoptotic cell death. More specifically, the structures relate to the structures of apoptotic active sites of mammalian alpha-fetoprotein (AFP) and albumin. Peptides mimicking the active site contain two sequences, Arg-Gly-Asp and Asp-X-X-Asp, wherein X means any amino acid. These sequences are needed in the same molecule for causing a wide range of biological activities. The peptides can be utilized to suppress apoptotic pathways by inhibiting the cytochrome c-mediated caspaseactivation. Thus, the peptides can be used to inhibit effects of apoptosis induced by oxidative stress, drugs, cytokines, Fas-ligand, alpha-fetoprotein, used to prevent apoptosis in culturing cells, in organ transplantation, in immunological autoimmune disorders and immunodeficiency syndrom induced by viral infection, or to diminish side cytotoxic effects after chemotherapy and radiation therapy.</p> |
申请公布号 |
WO2004033500(A1) |
申请公布日期 |
2004.04.22 |
申请号 |
WO2003FI00735 |
申请日期 |
2003.10.07 |
申请人 |
DUDICH, ELENA IVANOVNA;SEMENKOVA, LIDIA NIKOLAEVNA;DUDICH, IGOR VYACHESLAVOVITCH;TATULOV, EDWARD BORISOVITCH;ZUBOV, DMITRY LVOVICTH;KORPELA, TIMO, KALEVI |
发明人 |
DUDICH, ELENA IVANOVNA;SEMENKOVA, LIDIA NIKOLAEVNA;DUDICH, IGOR VYACHESLAVOVITCH;TATULOV, EDWARD BORISOVITCH;ZUBOV, DMITRY LVOVICTH;KORPELA, TIMO, KALEVI |
分类号 |
C07K16/18;A61K39/00;A61P37/00;C07K7/06;(IPC1-7):C07K16/42;C07K7/00;A61K38/00 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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