发明名称 |
METHOD FOR DETERMINING THE SUSCEPTIBILITY OF A SUBJECT TO INFECTION |
摘要 |
The present invention relates to diagnosis of neutropenia and to methods for determining susceptibility to infection. The invention also relates to metho ds for treating neutropenia and treating and/or preventing infections. The inventors have shown that a reduction in the levels of LL-37 in the saliva a nd neutrophils results in an increased susceptibility to periodontal infections caused mainly by bacteria from the normal oral flora. The present invention provides a method for determining the susceptibility of a subject to infection, which method comprises: i) providing a sample from said subject; ii) detecting any LL-37 present in said sample; iii) optionally comparing th e level of LL-37 in said sample to a control. sample; and iv) determining the susceptibility of said subject to infection, wherein no LL-37 or a low level of LL-37 indicates that said subject is susceptible to infection.
|
申请公布号 |
CA2501926(A1) |
申请公布日期 |
2004.04.22 |
申请号 |
CA20032501926 |
申请日期 |
2003.10.10 |
申请人 |
MABTECH AB |
发明人 |
ANDERSSON, MATS;BOMAN, HANS;PUTSEP, KATRIN;CARLSSON, GORAN |
分类号 |
A61K38/17;G01N33/68;(IPC1-7):G01N33/68;A61K38/00 |
主分类号 |
A61K38/17 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|