| 摘要 |
The present invention relates to methods and compositions for the diagnosis and treatment of metabolic disorders, including, but not limited to, obesity, diabetes, overweight anorexia, or cachexia. The present invention describes methods for the diagnostic evaluation and prognosis of various metabolic disorders and obesity, for the identification of subjects exhibiting a predisposition to such conditions, as well as the diagnostic monitoring of patients undergoing clinical evaluation for the treatment of metabolic disease and obesity, and for monitoring the efficacy of compounds in clinical trials. The invention further provides methods for identifying a compound capable of modulating a metabolic activity as well as treating a metabolic disorder. In addition, the invention provides methods useful for modulating a metabolic activity as well as for treating a subject having a metabolic disorder characterized by either aberrant CPA4 polypeptide activity or aberrant CPA4 nucleic acid expression.
|
