发明名称 |
Method and composition for inhibiting cardiovascular cell proliferation |
摘要 |
Cardiovascular cell proliferation in a blood vessel subjected to trauma, such as angioplasty, vascular graft, anastomosis, or organ transplant, can be inhibited by contacting the vessel with a polymer consisting of from 6 to about 30 amino acid subunits, where at least 50% of the subunits are arginine, and the polymer contains at least six contiguous arginine subunits. Exemplary polymers for this purpose include arginine homopolymers 7 to 15 subunits in length.
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申请公布号 |
US2004074504(A1) |
申请公布日期 |
2004.04.22 |
申请号 |
US20030442671 |
申请日期 |
2003.05.20 |
申请人 |
COOKE JOHN P.;FATHMAN GARRISON C.;ROTHBARD JONATHAN B.;UEMURA SHIRO;ROBBINS ROBERT C.;KOWN MURRAY H. |
发明人 |
COOKE JOHN P.;FATHMAN GARRISON C.;ROTHBARD JONATHAN B.;UEMURA SHIRO;ROBBINS ROBERT C.;KOWN MURRAY H. |
分类号 |
A61K38/00;A61K38/03;A61K38/08;A61K38/10;A61K38/16;A61L27/22;A61L27/34;A61L33/12;A61P7/04;A61P9/14;A61P43/00;C07K2/00;(IPC1-7):A61F2/06 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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