TF ANTAGONIST

摘要

This invention relates to conjugates of tissue factor (TF) antagonists and a domain that act to elicit a cytotoxic response. The conjugate bind TF with high affinity and specificity but do not initiate blood coagulation. In one embodiment of the present invention the TF antagonist is FVIIa polypeptides chemically inactivated in the active site. In another embodiment the TF antagonist is an antibody against TF. The invention also relates to pharmaceutical compositions comprising the conjugates as well as their use in the prophylaxis or treatment of diseases or disorders related to patho-physiological TF functions including cancer, inflammation, atherosclerosis and ischemia/reperfusion.