发明名称 |
Liver necrosis predictive genes |
摘要 |
The invention provides toxicity predictive genes that can be used to predict toxicity in response to one more agents. The invention provides for a method of predicting the liver toxicity in an individual to an agent. The method comprises obtaining a biological sample from an individual treated with the agent. The expression of one or more liver toxicity predictive genes in the sample is measured, wherein the genes are selected from a group consisting of partial gene sequences of genes identified as responsive to agents causing liver necrosis. The process generates a test expression profile. The test expression profile is used with a set of reference expression profiles in a Predictive Model to determine whether the agent will induce liver toxicity in the individual.
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申请公布号 |
US2004076974(A1) |
申请公布日期 |
2004.04.22 |
申请号 |
US20030404460 |
申请日期 |
2003.04.01 |
申请人 |
KIER LARRY D.;NOLAN TIMOTHY D.;SANKAR USHA;DERBEL MAHER |
发明人 |
KIER LARRY D.;NOLAN TIMOTHY D.;SANKAR USHA;DERBEL MAHER |
分类号 |
C12Q1/68;(IPC1-7):C12Q1/68;G06F19/00;G01N33/48;G01N33/50 |
主分类号 |
C12Q1/68 |
代理机构 |
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主权项 |
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地址 |
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