2-METHOXY-1,3,5-TRIAZINE DERIVATIVES, PREPARATION METHOD THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

摘要

PURPOSE: 2-Methoxy-1,3,5-triazine derivatives, a preparation method thereof and an antiviral pharmaceutical composition comprising the same are provided. The 2-Methoxy-1,3,5-triazine derivatives inhibit the growth of hepatitis C virus(HCV) and have low toxicity, so that they can be useful for the treatment of hepatitis caused by hepatitis C virus. CONSTITUTION: 2-methoxy-1,3,5-triazine derivatives represented by the formula(1) and pharmaceutically acceptable salts thereof are provided, wherein R is heterocycliccarbonyl or substituted phenyl. A method for preparing the 2-methoxy-1,3,5-triazine derivatives of the formula(1) comprises the steps of: (a) reacting 2-methoxy-6-£4-(4-morpholino) anilino|-4-chloro-1,3,5-triazine of the formula(2) with piperazine of the formula(3) to prepare 2-methoxy-6-£4-(4-morpholino) anilino|-4-(piperazin-1-yl) of the formula(4); and reacting the compound of the formula(4) with heterocycliccarbonyl chloride. A pharmaceutical composition for the prevention and treatment of hepatitis C comprises the 2-methoxy-1,3,5-triazine derivatives of the formula(1) and pharmaceutically acceptable salts thereof as effective components.