| 摘要 |
<p>The present invention is directed to a new process for granulating valproate compounds, such as divalproex sodium, in which the compound is melted in the absence of a binder and admixed with one or more excipients to produce granules. The resulting dosage forms have an increased drug loading factor in the range of 75 w/w% to 90 w/w%.</p> |
