| 摘要 |
FIELD: chemical-pharmaceutical industry, vaccines, drugs. SUBSTANCE: invention relates to compositions and methods for systemic delivery oral vaccines and therapeutic agents. Invention involves compositions and methods for oral delivery of antigens or therapeutic agent to the general circulation using a modified botulinic toxin that is alternated by modification or deletion with one of the following amino acids: His(229), Glu(230) and His(223) that is able to transport from intestine to the general circulation but has no toxic properties. EFFECT: reduced toxicity. 9 cl, 2 dwg
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