POLYMETHYLIDENEMALONATE-BASE NEW MICROSPHERES, METHODS FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF

摘要

FIELD: pharmacy. SUBSTANCE: invention relates to microspheres used as vector-particles designated for transporting biologically active substances, especially hydrophilic substances (peptides and proteins) for oral administration. Microspheres are formed by continuous network made of a polymeric material-carrier based on polymethylmethylidenemalonate. Biologically active substance can be dispersed in a material-carrier. Continuous network shows dense properties or can include globules with an aqueous phase distributed in its. Microspheres are prepared by the double emulsification method. Microspheres exhibit progressing and modulating decomposition kinetics and provides to carry out incapsulating hydrophilic substances of biological origin with the enhanced effectiveness and provide delivery of indicated substance to required body site also. EFFECT: improved preparing method, valuable properties of microspheres. 14 cl