| 摘要 |
FIELD: organic chemistry, biochemistry, nucleic acids. SUBSTANCE: invention relates to bicyclonucleoside analogs of the general formula (1) and oligonucleotides based on thereof comprising one or some structural units of the general formula (1a) wherein R1 represents hydrogen atom, protecting group, phosphoric acid group and others; R2 represents azido-group or amino-group that can be substituted; B represents purine-9-yl or 2-oxo-1,2-dihydropyrimidine- 1-yl group that can be substituted with one or some substituents. Oligonucleotides can be used as anti-sense or antigenic agents. EFFECT: valuable biological and biochemical properties of compounds. 15 cl, 1 dwg, 3 tbl |
