发明名称 EP4 receptor inhibitors to treat rheumatoid arthritis.
摘要 This invention provides a compound of the following formula: or salts thereof, and a compound of the following formula: or salts thereof, wherein Y 1 , Y 2 , Y 3 and Y 4 are independently selected from N, CH, etc.; R 1 is H, C 1-8 alkyl, etc.; A is an optionally substituted benzene or pyridine ring; B is C 2-6 alkylene etc.; W is NH or O; and P is H, protecting group etc.. These compounds are useful as intermediates for the preparation of compounds for the treatment of medical conditions mediated by prostaglamndin such as pain, fever or inflammation, etc.
申请公布号 ZA200302991(B) 申请公布日期 2004.04.16
申请号 ZA20030002991 申请日期 2003.04.16
申请人 PFIZER INC. 发明人 AUDOLY, LAURENT, PASCAL;TAKAKO OKUMURA;MASATO SHIMOJO
分类号 G01N33/48;A61K31/00;A61K31/4178;A61K31/4184;A61K31/4188;A61K31/427;A61K31/437;A61K31/4439;A61K31/444;A61K31/454;A61K31/4725;A61K31/506;A61K31/52;A61K31/64;A61K45/00;A61P1/00;A61P1/02;A61P1/04;A61P3/10;A61P5/00;A61P7/02;A61P7/04;A61P7/08;A61P9/00;A61P9/10;A61P9/12;A61P9/14;A61P11/02;A61P11/06;A61P13/12;A61P15/04;A61P15/06;A61P17/00;A61P17/02;A61P17/16;A61P19/02;A61P19/06;A61P19/08;A61P19/10;A61P21/00;A61P25/00;A61P25/02;A61P25/04;A61P25/06;A61P25/20;A61P25/28;A61P27/00;A61P27/06;A61P29/00;A61P31/12;A61P31/16;A61P31/18;A61P35/00;A61P35/04;A61P37/00;A61P37/02;A61P37/06;A61P37/08;A61P41/00;A61P43/00;C07D235/06;C07D235/08;C07D235/10;C07D235/12;C07D235/14;C07D235/16;C07D235/30;C07D401/04;C07D401/06;C07D401/12;C07D403/04;C07D403/06;C07D403/12;C07D413/12;C07D417/04;C07D417/12;C07D471/04;C07D473/00;C07D491/04;C07D491/048;C07D491/056;C07D521/00;G01N33/15;G01N33/50 主分类号 G01N33/48
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