Amyloid precursor protein and APP-deprived peptides inhibit tumor growth and metastasis

摘要

Amyloid precursor protein and non-glycosylated peptides derived therefrom especially from the Abeta domain of amyloid precursor protein are useful in prevention or treatment of cancer, and for immunostimulation in individuals with compromised immune systems. A peptide comprising residues 1-42 of the amyloid precursor protein, as well as smaller fragments and analogs of this peptide, which demonstrate the anti-cancer activity, are disclosed. A peptide comprising residues 1-16 of the amyloid precursor protein is one currently preferred active fragment. Pharmaceutical compositions comprising these peptides, and methods of using them to prevent or inhibit tumor growth and metastases are disclosed. Methods of gene therapy using APP or APP-derived peptides are also disclosed for treatment of cancer and for immunostimulation.