DNA DAMAGE REPAIR POLYPEPTIDE AND USES THEREOF

摘要

This invention relates to the identification of a polypeptide component of the ATM-dependent DNA damage signalling pathway which interacts with other DNA damage response factors, including the MRE11 complex and 53BP1. Modulation of the interactions of this polypeptide, which is termed MDC1 (mediator of DNA damage checkpoint protein 1), may have therapeutic applications, for example in the treatment of cancer or viral infection.