VERFAHREN ZUR HERSTELLUNG VON BETA-LACTAMDERIVATEN

摘要

A process for preparing a beta -lactam halide compound represented by the formula (2) characterized by halogenating the allenyl group of an allenyl beta -lactam compound represented by the formula (1) with a cupric halide and a metal halide to obtain the beta -lactam halide compound wherein R<1> is a hydrogen atom or amino or protected amino, R<2> is a hydrogen atom, halogen atom, lower alkoxyl, lower acyl, or lower alkyl having a hydroxyl group or protected hydroxyl group as a substituent, R<3> is a hydrogen atom or carboxylic acid protecting group, and R<4> is a hydrocarbon group which may have a substituent, or the group -S-S(O)n-Ar, n being 0 to 2, Ar being aryl which may have a substituent wherein R<1>, R<2>, R<3> and R<4> are the same as defined above, X and Y are each halogen atom.