METHOD OF SCREENING FOR ANTIDIABETIC AGENTS

摘要

A method of screening for an antidiabetic agent that lowers blood glucose level without inducing obesity and/or insulin resistance, is provided. The method comprises measuring the expression level of a nuclear peroxisome proliferator-activated receptor g (PPARg)-induced adipogenic gene in mature adipocytes in the presence of a test compound or a PPARg full agonist and selecting a compound that results in an expression level significantly lower than that measured using the PPARg full agonist. The method may further comprise the same steps except for using differentiating adipocytes to select a compound that results in an expression level comparable to or higher than that measured using the PPARg full agonist. A kit used for the above screening method, a compound obtainable by the screening method, a pharmaceutical composition containing such a compound, and a method lowering the blood glucose level without causing obesity and/or insulin resistance using the compound, are also provided.