NOVEL MHC II ASSOCIATED PEPTIDES

摘要

The present invention provides novel naturally-processed antigenic peptides which are candidate tumor antigens in melanoma and other tumors. These antigenic peptides are presented by human MHC class II HLA-DR molecules. The y originate from the translation factor eIF-4A, the IFN-gamma-inducible protei n p78, the cytoskeletal protein vimentin and the iron~binding surface protein melanotransferrin. The antigenic peptides of the present invention can be us ed as markers in diagnosis of the respective tumors and in therapy as anti-tumo r vaccines.