| 摘要 |
The technical features mentioned in the abstract do not include a reference sign between parentheses (PCT Rule 8.1(d)). Methods and devices are provided for detecting and confirming the identity of analytes such as threat agents, particularly analytes which are air or fluid borne. The methods comprise providing an affinity reagent having a known charge density in a medium whic h is capable of conducting electrical current, and the devices comprise a sens or as depicted in the figure below. Figure 4 (a) depicts the probe module porti on of the sensor, comprising a bulb (26), delivery tubes (27) and probe chamber s (28), and is connected to the power sources (batteries, 24) and the LED (designated "L", 25). The chip (29) comprising an array of discrete transistors (30) is connected to the probe module to enable deployment of th e probe reagents to the transistor array. Analyte identity is probed by manipulation of the charge density of the affinity reagent~analyte complex, including methods comprising altering probe conditions for different pH solutions, charge, a secondary affinity reagent, or combinations thereof. Methods and devices are provided for detecting and confirming the identity o f analytes such as threat agents, particularly analytes which are air or fluid borne. The methods compriseproviding an affinity reagent having a known charge density in a medium which is capable of conducting electrical current , and the devices comprise a sensor as depicted in the figure below. Figure 4 (a) depicts the probe module portion of the sensor, comprising a bulb (26), delivery tubes (27) and probe chambers (28), and is connected to the power sources (batteries, 24) and the LED (designated "L", 25). The chip (29) comprising an array of discrete transistors (30) is connected to the probe module to enable deployment of the probe reagents to the transistor array. Analyte identity is probed by manipulation of the charge density of the affinity reagent-analyte complex, including methods comprising altering prob e conditions for different pH solutions, charge, a secondary affinity reagent, or combinations thereof.
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