The present invention provides common ligand mimics that act as common ligands for a receptor family. The present invention also provides bi-ligands containing these common ligand mimics. Bi-ligands of the invention provide enhanced affinity and/or selectivity of ligand binding to a receptor or receptor family through the synergistic action of the common ligand mimic and specificity ligand which compose the bi-ligand. The present invention also provides combinatorial libraries containing the common ligand mimics and bi-ligands of the invention. Further, the present invention provides methods for manufacturing the common ligand mimics and bi-ligands of the invention and methods for assaying the combinatorial libraries of the invention.
申请公布号
WO03083063(A3)
申请公布日期
2004.04.15
申请号
WO2003US09086
申请日期
2003.03.21
申请人
TRIAD THERAPEUTICS, INC.;LANG, HENGYUAN;CHANG, EDCON;CEFALO, DUSTIN;FRYSZMAN, OLGA;YU, LIN
发明人
LANG, HENGYUAN;CHANG, EDCON;CEFALO, DUSTIN;FRYSZMAN, OLGA;YU, LIN