发明名称 Biodegradable poly(beta-amino esters) and uses thereof
摘要 Poly(beta-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. A system for preparing and screening polymers in parallel using semi-automated robotic fluid delivery systems is also provided.
申请公布号 US2004071654(A1) 申请公布日期 2004.04.15
申请号 US20030446444 申请日期 2003.05.28
申请人 ANDERSON DANIEL G.;LYNN DAVID M.;AKINC AKIN;LANGER ROBERT S. 发明人 ANDERSON DANIEL G.;LYNN DAVID M.;AKINC AKIN;LANGER ROBERT S.
分类号 G01N33/50;A61K9/50;A61K9/51;A61K9/56;A61K9/58;A61K38/00;A61K39/00;A61K45/00;A61K47/18;A61K47/22;A61K47/34;A61K47/48;A61K48/00;A61P31/00;A61P31/04;A61P31/10;A61P31/12;C07D207/08;C07D211/26;C07D233/02;C07D233/04;C07D233/61;C07D295/12;C08G63/40;C08G63/685;C08G69/44;C08G73/02;C08G73/06;C08G85/00;C08L67/02;C08L67/04;C08L77/04;C08L79/02;C08L89/00;C08L99/00;C08L101/16;C12N15/09;C12N15/88;G01N33/15;(IPC1-7):A61K31/785;C08G63/44 主分类号 G01N33/50
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