IMIDAZOLE, THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT AND/OR PREVENTION OF POLLAKIURIA OR URINARY INCONTINENCE

摘要

A large conductance calcium-activated K channel opener comprising as an active ingredient a nitrogen-containing 5-membered heterocyclic compound represented by the following formula (I): wherein X represents N-R<4>, O or S, R<1> and R <2> each independently represent hydrogen, halogen carboxyl, amino, lower alkyl, lower alkoxycarbonyl, lower alkenyl, cyclo-lower alkyl, carbamoyl, aryl, heterocyclic or heterocyclic-substituted carbonyl group, R<3> represents aryl, heterocyclic or lower alkyl group, and R<4> represents hydrogen or lower alkyl group, or a pharmaceutically acceptable salt thereof and its use for the preparation of a medicament for the phophylaxis and/or treatment of pollakiuria or urinary incontinence.