FACTOR PARTICIPATING IN TRANSCRIPTIONAL REGULATION

摘要

HDART binds to HDAC (histone deacetylase) and functions as a repressor. Also, HDART directly binds to Skip, which functions as a transcriptional coactivator of a nuclear receptor, to inhibit the transcription of the nuclear receptor. Moreover, HDART can bind to HDAC, which is one of transcriptional corepressors of a nuclear receptor, to thereby strongly inhibit the transcription via histone deacetylation of HDAC. On the other hand, a dominant negative peptide of HDART is obtained and it is confirmed that this peptide activates transcription on the contrary to the full-length HDART protein. In particular, this peptide is superior to all-trans retinoic acid (ATRA) in the activity to activate transcription of retinoic acid receptor.