发明名称 |
Modified human brain-derived neutrophic factor (bdnf) with reduced immunogenicity |
摘要 |
The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human brain-derived neutrophic factor (BDNF) to result in BDNF proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.
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申请公布号 |
US2004072291(A1) |
申请公布日期 |
2004.04.15 |
申请号 |
US20030467207 |
申请日期 |
2003.08.05 |
申请人 |
CARR FRANCIS J.;CARTER GRAHAM;JONES TIM;WILLIAMS STEPHEN |
发明人 |
CARR FRANCIS J.;CARTER GRAHAM;JONES TIM;WILLIAMS STEPHEN |
分类号 |
C12N15/02;A61K9/70;A61K38/00;A61K38/11;A61K38/18;A61K38/22;A61K47/02;A61K47/12;A61P25/00;A61P25/28;C07K7/08;C07K14/475;C07K14/48;C07K14/54;C07K16/18;C07K16/28;C07K16/30;C07K16/46;C12N15/12;G06F19/16;G06F19/18;(IPC1-7):C12P21/02;C12N5/06;C07H21/04 |
主分类号 |
C12N15/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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